陈海艳老师|结肠癌错配修复蛋白报告模版

华夏病理 2018-06-13 2859 评论

[导读] 6月9号晚，陈海艳老师讲解了《结直肠癌的错配修复蛋白免疫组化解读挑战》，有网友提出希望老师可以提供“结肠癌错配修复蛋白报告模版”，现公布如下：

MSS

- Immunohistochemical stains for mismatch repair proteins were performed. Expression of the DNA mismatch repair proteins MLH1, MSH2, MSH6 and PMS2 is retained in tumor cells. This indicates a low likelihood of tumor microsatellite instability (MSI) or Lynch syndrome.

MSS

- 错配修复蛋白免疫组化染色结果:DNA错配修复蛋白（MLH1、MSH2、MSH6和PMS2）在肿瘤细胞中全部表达，提示肿瘤微卫星不稳定性（MSI）或林奇综合征可能性低。

MSI

- Immunohistochemical stains for mismatch repair proteins were performed.

Immunohistochemical expression of the DNA mismatch repair proteins in tumor cells:

MLH1 and PMS2 are lostMSH2 and MSH6 are retained.

These results indicate a high likelihood of tumor microsatellite instability (MSI), most likely sporadic (epigenetic) type, but additional molecular testing (e.g., BRAF mutation) would be required to exclude Lynch syndrome with certainty.

MSI

- 错配修复蛋白免疫组化染色结果：DNA错配修复蛋白在肿瘤细胞中：MLH1和PMS2缺失；MSH2和MSH6表达；提示肿瘤微卫星不稳定性的可能性高，最大可能为散发性，但需要进一步分子检测（如BRAF突变）以确切地排除林奇综合征。