资讯频道

陈海艳老师|结肠癌错配修复蛋白报告模版

 华夏病理 1197 评论
[导读] 6月9号晚,陈海艳老师讲解了《结直肠癌的错配修复蛋白免疫组化解读挑战》,有网友提出希望老师可以提供“结肠癌错配修复蛋白报告模版”,现公布如下:

点击观看陈海艳老师讲座视频(结直肠癌的错配修复蛋白免疫组化解读挑战)

MSS               

- Immunohistochemical stains for mismatch repair proteins were performed. Expression of the DNA mismatch repair proteins MLH1, MSH2, MSH6 and PMS2 is retained in tumor cells. This indicates a low likelihood of tumor microsatellite instability (MSI) or Lynch syndrome. 

MSS

- 错配修复蛋白免疫组化染色结果:DNA错配修复蛋白(MLH1、MSH2、MSH6和PMS2)在肿瘤细胞中全部表达,提示肿瘤微卫星不稳定性(MSI)或林奇综合征可能性低。

MSI                

- Immunohistochemical stains for mismatch repair proteins were performed.

Immunohistochemical expression of the DNA mismatch repair proteins in tumor cells:

MLH1 and PMS2 are lostMSH2 and MSH6 are retained.

These results indicate a high likelihood of tumor microsatellite instability (MSI), most likely sporadic (epigenetic) type, but additional molecular testing (e.g., BRAF mutation) would be required to exclude Lynch syndrome with certainty.

MSI

- 错配修复蛋白免疫组化染色结果:DNA错配修复蛋白在肿瘤细胞中:MLH1和PMS2缺失;MSH2和MSH6表达;提示肿瘤微卫星不稳定性的可能性高,最大可能为散发性,但需要进一步分子检测(如BRAF突变)以确切地排除林奇综合征。

本站欢迎原创文章投稿,来稿一经采用稿酬从优,投稿邮箱[email protected]

相关阅读

  •   数据加载中

我要评论

0条评论